Mutations and Fitness

I’m still analyzing the mtDNA Dataset I’ve been working on, and I discovered that about 3.7% of the genomes exhibit properties consistent with significant mutations from an ancestor. This is also true of the genomes that have a roughly 70% match to Denisovan mtDNA, which includes many Ashkenazi Jews. Because mtDNA is inherited as a single entire genome, with only few if any mutations, it must be the case that these populations were the result of significant selection, there’s simply no other credible argument to the contrary. Because mtDNA is fundamental to the production of ATP (i.e., energy), it’s reasonable to conclude that these populations are extremely fit, for the simple reason, that again, they must have engaged in selection over significant periods of time. Keep in mind, many living people are today a 99% match to a 4,000 year old Ancient Egyptian genome, suggesting that in the absence of mutation and selection, mtDNA really doesn’t change much. If you’re selecting mtDNA mutations, it’s fair to conclude that you’re selecting for overall health and energy, which is possibly connected to brain power as well. There are thankfully some Finnish athletes in the NIH Database, and many Finns are also closely related to Denisovans, though again, the match count is roughly 70%, implying again significant mutation and selection. Note however the populations that exhibit significant mutations are geographically widespread, and I noted the Denisovans, only because it’s such an obvious case, as you have a literally archaic bloodline, that plainly underwent significant mutation and selection. I will follow up with something more formal shortly.


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